FTO expression is regulated by availability of essential amino acids
نویسندگان
چکیده
منابع مشابه
The essential amino-acids.
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It has been known for many years that free amino acids are present in the blood and that their concentration increases after ingestion of a meal. In 1912 Van Slyke and Meyer (1) reported the presence of amino nitrogen in the non-protein fraction of the blood of dogs and that its concentra,tion increased after feeding meat. Abel et al. (2), using a vivi-diffusion apparatus, observed that free am...
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Fat mass and obesity associated gene (FTO) is the first gene associated with body mass index (BMI) and risk for diabetes. FTO is highly expressed in the brain and pancreas, and is involved in regulating dietary intake and energy expenditure. To investigate the transcriptional regulation of FTO expression, we created 5'-deletion constructs of the FTO promoter to determine which transcription fac...
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ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2012
ISSN: 0307-0565,1476-5497
DOI: 10.1038/ijo.2012.77